Jichi Medical University, Center for Molecular Medicine, Nishimura lab

Bio-imaging techniques that enable detection of vascular function, blood flow and inflammatory changes that precede histological changes are very useful for examining lifestyle-related diseases, such as metabolic syndrome, as well as tumors and thrombosis.

With the development of novel optical observation systems and a variety of fluorescent probes in recent years, we are now able to observe blood flow and cell kinetics in solid organs whose thickness preclude the use of transmitted light.

skeletal muscle

intestine

white adipose tissue

kidney

artery

microcirculation

CAG-eGFP
Dextran
Hoechst

Fig.1 In vivo imaging visuals
green:CAG-eGFP, red:Dextran, blue:Hochst, Intravital visualization by two photon microscope

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