Publication | Satoshi Nishimura Lab

2018

Turbulence Activates Platelet Biogenesis to Enable Clinical Scale Ex Vivo Production.EN

Ito Y, Nakamura S, Sugimoto N, Shigemori T, Kato Y, Ohno M, Sakuma S, Ito K, Kumon H, Hirose H, Okamoto H, Nogawa M, Iwasaki M, Kihara S, Fujio K, Matsumoto T, Higashi N, Hashimoto K, Sawaguchi A, Harimoto KI, Nakagawa M, Yamamoto T, Handa M, Watanabe N, Nishi E, Arai F, Nishimura S, Eto K.

Cell. 2018 Jul 26;174(3):636-648.e18.

Von Willebrand Factor Aggravates Hepatic Ischemia-Reperfusion Injury by Promoting Neutrophil Recruitment in Mice.EN

Urisono Y, Sakata A, Matsui H, Kasuda S, Ono S, Yoshimoto K, Nishio K, Sho M, Akiyama M, Miyata T, Okuchi K, Nishimura S, Sugimoto M.

Thromb Haemost. 2018 Apr;118(4):700-708.

Bone Imaging: Platelet Formation Dynamics.EN

Sakata A, Nishimura S.

Methods Mol Biol. 2018;1763:23-28.

2017

Transplantation of bioengineered rat lungs recellularized with endothelial and adipose-derived stromal cells.EN

Doi R, Tsuchiya T, Mitsutake N, Nishimura S, Matsuu-Matsuyama M, Nakazawa Y, Ogi T, Akita S, Yukawa H, Baba Y, Yamasaki N, Matsumoto K, Miyazaki T, Kamohara R, Hatachi G, Sengyoku H, Watanabe H, Obata T, Niklason LE, Nagayasu T.

Sci Rep. 2017 Aug 16;7(1):8447.

CRISPR/Cas9-mediated genome editing via postnatal administration of AAV vector cures haemophilia B mice.EN

Ohmori T, Nagao Y, Mizukami H, Sakata A, Muramatsu SI, Ozawa K, Tominaga SI, Hanazono Y, Nishimura S, Nureki O, Sakata Y.

Sci Rep. 2017 Jun 23;7(1):4159.

Hemostatic function to regulate perioperative bleeding in patients undergoing spinal surgery: A prospective observational study.EN

Kimura A, Ohmori T, Sakata A, Endo T, Inoue H, Nishimura S, Takeshita K.

PLoS One. 2017 Jun 16;12(6):e0179829.

Selective Inhibition of ADAM17 Efficiently Mediates Glycoprotein Ibα Retention During Ex Vivo Generation of Human Induced Pluripotent Stem Cell-Derived Platelets.EN

Hirata S, Murata T, Suzuki D, Nakamura S, Jono-Ohnishi R, Hirose H, Sawaguchi A, Nishimura S, Sugimoto N, Eto K.

Stem Cells Transl Med. 2017 Mar;6(3):720-730.

2015

IL-1alph induces thrombopoiesis through megakaryocyte rupture in response to acute platelet needs.EN

Nishimura S, Nagasaki M, Kunishima S, Sawaguchi A, Sakata A, Sakaguchi H, Ohmori T, Manabe I, J Italiano, Ryu T, Takayama N, Komuro I, Kadowaki T, Eto K, Nagai R.

J Cell Biol. 2015; 209(3): 453-66.

TMEM16F is required for phosphatidylserine exposure and microparticle release in activated mouse platelets.EN

Fujii T, Sakata A, Nishimura S, Eto K, Nagata S.

Proc Natl Acad Sci USA. 2015 (in press)

The frequency of peripheral blood CD4+FoxP3+ regulatory T cells in women with pre-eclampsia and those with high-risk factors for pre-eclampsia.EN

Nagayama S, Ohkuchi A, Shirasuna K, Takahashi K, Suzuki H, Hirashima C, Sakata A, Nishimura S, Takahashi M, Matsubara S.

Hypertens Pregnancy. 2015 (in press)

2014

ENPP2 contributes to adipose Tissue expansion and insulin resistance in diet-induced obesity. EN

Nishimura S, Nagasaki M, Okudaira S, Aoki J, Ohmori T, Ohkawa R, Nakamura K, Igarashi K, Yamashita H, Eto K, Uno K, Hayashi N, Kadowaki T, Komuro I, Yatomi Y, Nagai R.

Diabetes. 2014; 63(12): 4154-64.

Paxillin is an intrinsic negative regulator of platelet activation in mice.EN

Sakata A, Ohmori T, Nishimura S, Suzuki H, Madoiwa S, Mimuro J, Kario K, Sakata Y.

Thromb J. 2014; 12(1): 1.

Combination of thrombin-antithrombin complex, plasminogen activator inhibitor-1, and protein C activity for early identification of severe coagulopathy in initial phase of sepsis: a prospective observational study.EN

Koyama K, Madoiwa S, Nunomiya S, Koinuma T, Wada M, Sakata A, Ohmori T, Mimuro J, Sakata Y.

Crit Care. 2014; 18(1): R13.

Expandable Megakaryocyte Cell Lines Enable Clinically Applicable Generation of Platelets from Human Induced Pluripotent Stem Cells. EN

Nakamura S, Takayama N, Hirata S, Seo H, Endo H, Ochi K, Fujita K, Koike T, Harimoto K, Dohda T, Watanabe A, Okita K, Takahasi N, Sawaguchi A, Yamanaka S, Nakauchi H, Nishimura S, Eto K.

Cell Stem Cell. 2014; 14(4): 535-48.

Macrophage-inducible C-type lectin underlies obesity-induced adipose tissue fibrosis.EN

Tanaka M, Ikeda K, Suganami T, Komiya C, Ochi K, Shirakawa I, Hamaguchi M, Nishimura S, Manabe I, Matsuda T, Kimura K, Inoue H, Inagaki Y, Aoe S, Yamasaki S, Ogawa Y.

Nat Commun. 2014; 5: 4982.

Simultaneous downregulation of KLF5 and Fli1 is a key feature underlying systemic sclerosis.EN

Noda S, Asano Y, Nishimura S, Taniguchi T, Fujiu K, Manabe I, Nakamura K, Yamashita T, Saigusa R, Akamata K, Takahashi T, Ichimura Y, Toyama T, Tsuruta D, Trojanowska M, Nagai R, Sato S.

Nat Commun. 2014; 5: 5797.

Estrogen dependence of PDE5 inhibitor efficacy in female heart disease.EN

Sasaki H, Nagayama T, Blanton RM, Seo K, Zhang M, Zhu G, Lee DI, Bedja D, Hsu S, Tsukamoto O, Takashima S, Kitakaze M, Mendelsohn ME, Karas RH, Kass DA, Takimoto E.

J Clin Invest. 2014; 124(6): 2464-2471.

TUBB1 mutation disrupting microtubule assembly impairs proplatelet formation and results in congenital macrothrombocytopenia.EN

Kunishima S, Nishimura S, Suzuki H, Imaizumi M, Saito H.

Eur J Haematol. 2014; 92(4): 276-82.

2013

Adipose natural regulatory B cells negatively control adipose tissue inflammation.EN

Nishimura S, Manabe I, Takaki S, Nagaskai M, Ostu M, Yamashita H, Sugita J, Yoshimura K, Eto K, Komuro I, Kadowaki T, Nagai R.

Cell Metab. 2013; 18: 759-766.

The prevalence of neutralizing antibodies against adeno-associated virus capsids is reduced in young Japanese individuals.EN

Mimuro J, Mizukami H, Shima M, Matsushita T, Taki M, Muto S, Higasa S, Sakai M, Ohmori T, Madoiwa S, Ozawa K, Sakata Y.

J Med Virol. 2014; 86(11): 1990-7.

2012

In vivo imaging visualizes discoid platelet aggregations without endothelium disruption and implicates contribution of inflammatory cytokine and integrin signaling.EN

Nishimura S, Manabe I, Nagasaki M, Kakuta S, Iwakura Y, Takayama N, Ooehara J, Otsu M, Kamiya A, Petrich B, Urano T, Kadono T, Sato S, Aiba A, Yamashita H, Sugiura S, Kadowaki T, Nakauchi H, Eto K, Nagai R.

Blood. 2012; 119(8): e45-56.

Inhibition of Stabilin-2 elevates circulating hyaluronic acid levels and prevents tumor metastasis.EN

Hirose Y, Saijou E, Sugano Y, Takeshita F, Nishimura S, Nonaka H, Chen Y-R, Sekine K, Kido T, Nakamura T, Kato S, Kanke T, Nakamura K, Nagai R, Ochiya T, Miyajima A.

Proc Nat Acad Sci USA. 2012; 109(11): 4263-8.

Immune response against serial infusion of factor VIII antigen through an implantable venous-access device system in haemophilia A mice.EN

Madoiwa, S., Kobayashi, E., Kashiwakura, Y., Sakata, A., Yasumoto, A., Ohmori, T., Mimuro, J., Sakata, Y.

Haemophilia. 2012; 18(3): e323-30.

Porcine model of hemophilia A.EN

Kashiwakura, Y., Mimuro, J., Onishi, A., Iwamoto, M., Madoiwa, S., Fuchimoto, D., Suzuki, S., Suzuki, M., Sembon, S., Ishiwata, A., Yasumoto, A., Sakata, A., Ohmori, T., Hashimoto, M., Yazaki, S., Sakata, Y.

PLoS One. 2012; 7: e49450.

2011

Impaired insulin signaling in endothelial cells reduces insulin-induced glucose uptake by skeletal muscle. EN

Kubota T, Kubota N, Kumagai H, Yamaguchi S, Kozono H, Takahashi T, Inoue M, Itoh S, Takamoto I, Sasako T, Kumagai K, Kawai T, Hashimoto S, Kobayashi T, Sato M, Tokuyama K, Nishimura S, Tsunoda M, Ide T, Murakami K, Yamazaki T, Ezaki O, Kawamura K, Masuda H, Moroi M, Sugi K, Oike Y, Shimokawa H, Yanagihara N, Tsutsui M, Terauchi Y, Tobe K, Nagai R, Kamata K, Inoue K, Kodama T, Ueki K, Kadowaki T.

Cell Metab. 2011; 13(3): 294-307.

Degradation of cross-linked fibrin by leukocyte elastase as alternative pathway for plasmin-mediated fibrinolysis in sepsis-induced disseminated intravascular coagulation.EN

Madoiwa, S., Tanaka, H., Nagahama,Y., Dokai, M., Kashiwakura,Y., Ishiwata,A., Sakata, A., Yasumoto,A., Ohmori,T., Mimuro,J., Sakata,Y.

Thromb Res. 2011; 127: 349-355.

Local regulation of neutrophil elastase activity by endogenous a1-antitrypsin in lipopolysaccharide primed hematological cells.EN

Dokai, M., Madoiwa, S., Yasumoto ,A.,Kashiwakura, Y., Ishiwata, A., Sakata, A., Makino, N., Ohmori ,T., Mimuro, J., Sakata, Y.

Thromb Res. 2011;128: 283-292.

Predictive blood coagulation markers for early diagnosis of venous thromboembolism after total knee joint replacement.EN

Watanabe, H., Madoiwa, S., Sekiya, H., Nagahama, Y., Matsuura, S., Kariya ,Y., Ohmori ,T., Mimuro, J., Hoshino, Y., Hayasaka ,S., Sakata, Y.

Thromb Res. 2011; 128(6): e137-43.

Thrombospondin-4 Is required for stretch-mediated contractility augmentation in cardiac muscle. EN

Cingolani OH, Kirk JA, Seo K, Koitabashi N, Lee DI, Ramirez-Correa G, Bedja D, Barth AS, Moens AL, Kass DA.

Circ Res. 2011; 109: 1410-1414.

2010

Cardiac fibroblasts are essential for the adaptive response of the murine heart to pressure overload.EN

Takeda N, Manabe I, Uchino Y, Eguchi K, Matsumoto S, Nishimura S, Shindo T, Sano M, Otsu K, Snider P, Conway SJ, Nagai R.

J Clin Invest. 2010; 120(1): 254-65.

Lnk/Sh2b3 regulates integrin alpha-IIb-beta3 outside-in signaling in platelets leading to stabilization of developing thrombus in vivo. EN

Takizawa H*, Nishimura S*, Takayama N, Oda A, Nishikii H, Morita Y, Kakinuma S, Yamazaki S, Okamura S, Tamura N, Goto S, Sawaguchi A, Manabe I, Takatsu K, Nakauchi H, Takaki S, Eto K.

J Clin Invest. 2010; 120(1): 179-190.

Transient activation of c-MYC expression is critifal for efficient platelet generation from human induced pluripotent stem cells.EN

Takayama N, Nishimura S, Nakamura S, Shimizu T, Ohnishi R, Endo H, Yamaguchi T, Otsu M, Nishimura K, Nakanishi M, Sawaguchi A, Nagai R, Takahashi K, Yamanaka S, Nakauchi H, Eto K.

J Exp Med. 2010; 207(13): 2817-2830.

Mutant macaque factor IX T262A:A tool for hemophilia B gene therapy studies in macaques.EN

Ishiwata, A., Mimuro,J., Mizukami,H.,Kashiwakura,Y.,Yasumoto,A., Sakata,A.,Ohmori,T,, Madoiwa, S., Ono, F., Shima, M., Yoshioka, A., Ozawa, K.,Sakata,Y.

Thromb Res. 125(6):533-537. 2010.

Vinculin is indispensable for repopulation by hematopoietic stem cells, independent of integrin function.EN

Ohmori, T., Kashiwakura ,Y., Ishiwata, A., Madoiwa ,S., Mimuro ,J., Furukawa, Y., Sakata, Y.

J Biol Chem. 2010; 285(41): 31763-73.

Development of platelet-directed gene modification by lentiviral vector.EN

Ohmori, T., Madoiwa, S., Mimuro, J., Sakata, Y.

Rinsho Ketsueki. 2010; 51(8): 625-31.

2009

CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity.EN

Nishimura S^＊, Manabe I, Nagasaki M, Eto K, Yamashita H, Ohsugi M, Otsu M, Hara K, Ueki K, Sugiura S, Yoshimura K, Kadowaki T, Nagai R.

Nat Med. 2009; 15; 914-920.

Adipose tissue inflammation in obesity and metabolic syndrome.EN

Nishimura S, Manabe I, Nagai R.

Discov Med. 2009; 8(41): 55-60.

Induction of factor VIII-specific unresponsiveness by intrathymic factor VIII injection in murine hemophilia A.EN

Madoiwa, S., Yamauchi,T., Kobayashi ,E., Hakamata, Y., Dokai, M., Makino, N., Kashiwakura,Y., Ishiwata, A., Ohmori,T., Mimuro,J., Sakata,Y.

J Thromb Haemost. 2009; 7(5): 811-824.

2008以前

In vivo imaging in mice reveals local cell dynamics and inflammation in obese adipose tissue.EN

Nishimura S, Manabe I, Nagasaki M, Seo K, Yamashita H, Hosoya Y, Ohsugi M, Tobe K, Kadowaki T, Nagai R, Sugiura S.

J Clin Invest. 2008; 118(2): 710-21.

Responses of single-ventricular myocytes to dynamic axial stretching.EN

Nishimura S, Seo K, Nagasaki M, Hosoya Y, Yamashita H, Fujita H, Nagai R, Sugiura S.

Prog Biophys Mol Biol. 2008; 97(2-3): 282-97.

Adipogenesis in obesity requires close interplay between differentiating adipocytes, stromal cells, and blood vessels.EN

Nishimura S, Manabe I, Nagasaki M, Hosoya Y, Yamashita H, Fujita H, Ohsugi M, Tobe K, Kadowaki T, Nagai R, Sugiura S.

Diabetes. 2007; 56(6): 1517-26.

Microtubules modulate the stiffness of cardiomyocytes against shear stress.EN

Nishimura S, Nagai S, Katoh M, Yamashita H, Saeki Y, Okada J, Hisada T, Nagai R, Sugiura S.

Circ Res. 2006; 98(1): 81-7.

Carbon fiber technique for the investigation of single-cell mechanics in intact cardiac myocytes.EN

Sugiura S, Nishimura S, Yasuda S, Hosoya Y, Katoh K.

Nat Protoc. 2006; 1(3): 1453-7.

Membrane potential of rat ventricular myocytes responds to axial stretch in phase, amplitude and speed-dependent manners.EN

Nishimura S, Kawai Y, Nakajima T, Hosoya Y, Fujita H, Katoh M, Yamashita H, Nagai R, Sugiura S.

Cardiovasc Res. 2006; 72(3): 403-11.

Expression of green fluorescent protein impairs the force-generating ability of isolated rat ventricular cardiomyocytes.EN

Nishimura S, Nagai S, Sata M, Katoh M, Yamashita H, Saeki Y, Nagai R, Sugiura S.

Mol Cell Biochem. 2006; 286(1-2): 59-65.

Contractile dysfunction of cardiomyopathic hamster myocytes is pronounced under high load conditions.EN

Nishimura S, Yamashita H, Katoh M, Yamada KP, Sunagawa K, Saeki Y, Ohnuki Y, Nagai R, Sugiura S.

J Mol Cell Cardiol. 2005; 39(2): 231-9.

Three-dimensional simulation of calcium waves and contraction in cardiomyocytes using the finite element method.EN

Okada J, Sugiura S, Nishimura S, Hisada T.

Am J Physiol Cell Physiol. 2005; 288(3): C510-22.

Single cell mechanics of rat cardiomyocytes under isometric, unloaded, and physiologically loaded conditions.EN

Nishimura S, Yasuda S, Katoh M, Yamada KP, Yamashita H, Saeki Y, Sunagawa K, Nagai R, Hisada T, Sugiura S.

Am J Physiol Heart Circ Physiol. 2004; 287(1): H196-202.

Unloaded shortening increases peak of Ca2+ transients but accelerates their decay in rat single cardiac myocytes.EN

Yasuda S, Sugiura S, Yamashita H, Nishimura S, Saeki Y, Momomura S, Katoh K, Nagai R, Sugi H.

Am J Physiol Heart Circ Physiol. 2003; 285(2): H470-5.

和文雑誌等

生体分子イメージングによる微小循環の可視化と病態解析.EN

西村　智

臨床高血圧１. 2013; 19(4): 12-18.

出血性疾患の診断アプローチ.EN

大森　司

臨床血液. 2013; 54(10): 1888-1896.

血清パラオキソナーゼ活性は抗血小板薬投与下の凝集能と関連しない．EN

大森司, 矢野裕一郎, 坂田飛鳥, 池本智一, 新保昌久, 窓岩清治, 勝木孝明, 三室淳,

島田和幸, 苅尾七臣, 坂田洋一

日本血栓止血学会誌. 2012; 23(2): 200.

第FVIII因子感作血友病Aマウスにおけるマイクロボードを用いた連続的抗原投与モデルの構築．EN

窓岩清治, 小林英司, 坂田飛鳥, 柏倉裕志, 大森司, 三室淳, 坂田洋一

第34回日本血栓止血学会学術集会.東京, 2012.6/7-9.

日本血栓止血学会誌. 2012; 23(2): 197.

出血傾向・血小板減少症の鑑別診断．EN