Jichi Medical University, Center for Molecular Medicine, Nishimura lab

Jichi Medical University,
Center for Molecular Medicine,

Nishimura lab


ADDRESS:
3311-1 Yakushiji,
Shimotsuke-shi,
Tochigi,
Japan 329-0498 +81-285-44-2111


Please contact us for use of the image and video.

Publication

Home » Publication

IL-1alph induces thrombopoiesis through megakaryocyte rupture in response to acute platelet needs.EN

Nishimura S, Nagasaki M, Kunishima S, Sawaguchi A, Sakata A, Sakaguchi H, Ohmori T, Manabe I, J Italiano, Ryu T, Takayama N, Komuro I, Kadowaki T, Eto K, Nagai R. 
J Cell Biol. 2015; 209(3): 453-66. 

TMEM16F is required for phosphatidylserine exposure and microparticle release in activated mouse platelets.EN

Fujii T, Sakata A, Nishimura S, Eto K, Nagata S.

Proc Natl Acad Sci USA. 2015 (in press)

The frequency of peripheral blood CD4+FoxP3+ regulatory T cells in women with pre-eclampsia and those with high-risk factors for pre-eclampsia.EN

Nagayama S, Ohkuchi A, Shirasuna K, Takahashi K, Suzuki H, Hirashima C, Sakata A, Nishimura S, Takahashi M, Matsubara S.

Hypertens Pregnancy. 2015 (in press)

ENPP2 contributes to adipose Tissue expansion and insulin resistance in diet-induced obesity. EN

Nishimura S, Nagasaki M, Okudaira S, Aoki J, Ohmori T, Ohkawa R, Nakamura K, Igarashi K, Yamashita H, Eto K, Uno K, Hayashi N, Kadowaki T, Komuro I, Yatomi Y, Nagai R.

Diabetes. 2014; 63(12): 4154-64.

Paxillin is an intrinsic negative regulator of platelet activation in mice.EN

Sakata A, Ohmori T, Nishimura S, Suzuki H, Madoiwa S, Mimuro J, Kario K, Sakata Y.

Thromb J. 2014; 12(1): 1.

Combination of thrombin-antithrombin complex, plasminogen activator inhibitor-1, and protein C activity for early identification of severe coagulopathy in initial phase of sepsis: a prospective observational study.EN

Koyama K, Madoiwa S, Nunomiya S, Koinuma T, Wada M, Sakata AOhmori T, Mimuro J, Sakata Y.
Crit Care. 2014; 18(1): R13.

Expandable Megakaryocyte Cell Lines Enable Clinically Applicable Generation of Platelets from Human Induced Pluripotent Stem Cells. EN

Nakamura S, Takayama N, Hirata S, Seo H, Endo H, Ochi K, Fujita K, Koike T, Harimoto K, Dohda T, Watanabe A, Okita K, Takahasi N, Sawaguchi A, Yamanaka S, Nakauchi H, Nishimura S, Eto K. 

Cell Stem Cell. 2014; 14(4): 535-48.

Macrophage-inducible C-type lectin underlies obesity-induced adipose tissue fibrosis.EN

Tanaka M, Ikeda K, Suganami T, Komiya C, Ochi K, Shirakawa I, Hamaguchi M, Nishimura S, Manabe I, Matsuda T, Kimura K, Inoue H, Inagaki Y, Aoe S, Yamasaki S, Ogawa Y.

Nat Commun. 2014; 5: 4982.

Simultaneous downregulation of KLF5 and Fli1 is a key feature underlying systemic sclerosis.EN

Noda S, Asano Y, Nishimura S, Taniguchi T, Fujiu K, Manabe I, Nakamura K, Yamashita T, Saigusa R, Akamata K, Takahashi T, Ichimura Y, Toyama T, Tsuruta D, Trojanowska M, Nagai R, Sato S.
Nat Commun. 2014; 5: 5797.

Estrogen dependence of PDE5 inhibitor efficacy in female heart disease.EN

Sasaki H, Nagayama T, Blanton RM, Seo K, Zhang M, Zhu G, Lee DI, Bedja D, Hsu S, Tsukamoto O, Takashima S, Kitakaze M, Mendelsohn ME, Karas RH, Kass DA, Takimoto E.

J Clin Invest. 2014; 124(6): 2464-2471.

TUBB1 mutation disrupting microtubule assembly impairs proplatelet formation and results in congenital macrothrombocytopenia.EN

Kunishima S, Nishimura S, Suzuki H, Imaizumi M, Saito H.

Eur J Haematol. 2014; 92(4): 276-82.

Adipose natural regulatory B cells negatively control adipose tissue inflammation.EN

Nishimura S, Manabe I, Takaki S, Nagaskai M, Ostu M, Yamashita H, Sugita J, Yoshimura K, Eto K, Komuro I, Kadowaki T, Nagai R.

Cell Metab. 2013; 18: 759-766.

The prevalence of neutralizing antibodies against adeno-associated virus capsids is reduced in young Japanese individuals.EN

Mimuro J, Mizukami H, Shima M, Matsushita T, Taki M, Muto S, Higasa S, Sakai M, Ohmori TMadoiwa S, Ozawa K, Sakata Y.

J Med Virol. 2014; 86(11): 1990-7.

In vivo imaging visualizes discoid platelet aggregations without endothelium disruption and implicates contribution of inflammatory cytokine and integrin signaling.EN

Nishimura S, Manabe I, Nagasaki M, Kakuta S, Iwakura Y, Takayama N, Ooehara J, Otsu M, Kamiya A, Petrich B, Urano T, Kadono T, Sato S, Aiba A, Yamashita H, Sugiura S, Kadowaki T, Nakauchi H, Eto K, Nagai R.

Blood. 2012; 119(8): e45-56.

Inhibition of Stabilin-2 elevates circulating hyaluronic acid levels and prevents tumor metastasis.EN

Hirose Y, Saijou E, Sugano Y, Takeshita F, Nishimura S, Nonaka H, Chen Y-R, Sekine K, Kido T, Nakamura T, Kato S, Kanke T, Nakamura K, Nagai R, Ochiya T, Miyajima A.

Proc Nat Acad Sci USA. 2012; 109(11): 4263-8.

Immune response against serial infusion of factor VIII antigen through an implantable venous-access device system in haemophilia A mice.EN

Madoiwa, S., Kobayashi, E., Kashiwakura, Y., Sakata, A., Yasumoto, A., Ohmori, T., Mimuro, J., Sakata, Y.

Haemophilia. 2012; 18(3): e323-30.

Porcine model of hemophilia A.EN

Kashiwakura, Y., Mimuro, J., Onishi, A., Iwamoto, M., Madoiwa, S., Fuchimoto, D., Suzuki, S., Suzuki, M., Sembon, S., Ishiwata, A., Yasumoto, A., Sakata, A.Ohmori, T., Hashimoto, M., Yazaki, S., Sakata, Y. 

PLoS One. 2012; 7: e49450.

Impaired insulin signaling in endothelial cells reduces insulin-induced glucose uptake by skeletal muscle. EN

Kubota T, Kubota N, Kumagai H, Yamaguchi S, Kozono H, Takahashi T, Inoue M, Itoh S, Takamoto I, Sasako T, Kumagai K, Kawai T, Hashimoto S, Kobayashi T, Sato M, Tokuyama K, Nishimura S, Tsunoda M, Ide T, Murakami K, Yamazaki T, Ezaki O, Kawamura K, Masuda H, Moroi M, Sugi K, Oike Y, Shimokawa H, Yanagihara N, Tsutsui M, Terauchi Y, Tobe K, Nagai R, Kamata K, Inoue K, Kodama T, Ueki K, Kadowaki T.

Cell Metab. 2011; 13(3): 294-307.

Degradation of cross-linked fibrin by leukocyte elastase as alternative pathway for plasmin-mediated fibrinolysis in sepsis-induced disseminated intravascular coagulation.EN

Madoiwa, S., Tanaka, H., Nagahama,Y., Dokai, M., Kashiwakura,Y., Ishiwata,A., Sakata, A., Yasumoto,A., Ohmori,T., Mimuro,J., Sakata,Y.

Thromb Res. 2011; 127: 349-355. 

Local regulation of neutrophil elastase activity by endogenous a1-antitrypsin in lipopolysaccharide primed hematological cells.EN

Dokai, M., Madoiwa, S., Yasumoto ,A.,Kashiwakura, Y., Ishiwata, A., Sakata, A., Makino, N., Ohmori ,T., Mimuro, J., Sakata, Y.  

Thromb Res. 2011;128: 283-292.

Predictive blood coagulation markers for early diagnosis of venous thromboembolism after total knee joint replacement.EN

Watanabe, H., Madoiwa, S., Sekiya, H., Nagahama, Y., Matsuura, S., Kariya ,Y., Ohmori ,T., Mimuro, J., Hoshino, Y., Hayasaka ,S., Sakata, Y.

Thromb Res. 2011; 128(6): e137-43.

Thrombospondin-4 Is required for stretch-mediated contractility augmentation in cardiac muscle. EN

Cingolani OH, Kirk JA, Seo K, Koitabashi N, Lee DI, Ramirez-Correa G, Bedja D, Barth AS, Moens AL, Kass DA.

Circ Res. 2011; 109: 1410-1414.

Cardiac fibroblasts are essential for the adaptive response of the murine heart to pressure overload.EN

Takeda N, Manabe I, Uchino Y, Eguchi K, Matsumoto S, Nishimura S, Shindo T, Sano M, Otsu K, Snider P, Conway SJ, Nagai R.

J Clin Invest. 2010; 120(1): 254-65.

Lnk/Sh2b3 regulates integrin alpha-IIb-beta3 outside-in signaling in platelets leading to stabilization of developing thrombus in vivo. EN

Takizawa H*, Nishimura S*, Takayama N, Oda A, Nishikii H, Morita Y, Kakinuma S, Yamazaki S, Okamura S, Tamura N, Goto S, Sawaguchi A, Manabe I, Takatsu K, Nakauchi H, Takaki S, Eto K.
J Clin Invest. 2010; 120(1): 179-190. 

Transient activation of c-MYC expression is critifal for efficient platelet generation from human induced pluripotent stem cells.EN

Takayama N, Nishimura S, Nakamura S, Shimizu T, Ohnishi R, Endo H, Yamaguchi T, Otsu M, Nishimura K, Nakanishi M, Sawaguchi A, Nagai R, Takahashi K, Yamanaka S, Nakauchi H, Eto K.

J Exp Med. 2010; 207(13): 2817-2830.

Mutant macaque factor IX T262A:A tool for hemophilia B gene therapy studies in macaques.EN

Ishiwata, A., Mimuro,J., Mizukami,H.,Kashiwakura,Y.,Yasumoto,A., Sakata,A.,Ohmori,T,, Madoiwa, S., Ono, F., Shima, M., Yoshioka, A., Ozawa, K.,Sakata,Y.

Thromb Res. 125(6):533-537. 2010.

Vinculin is indispensable for repopulation by hematopoietic stem cells, independent of integrin function.EN

Ohmori, T., Kashiwakura ,Y., Ishiwata, A., Madoiwa ,S., Mimuro ,J., Furukawa, Y., Sakata, Y.

J Biol Chem. 2010; 285(41): 31763-73.

Development of platelet-directed gene modification by lentiviral vector.EN

Ohmori, T., Madoiwa, S., Mimuro, J., Sakata, Y.

Rinsho Ketsueki. 2010; 51(8): 625-31.

CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity.EN

Nishimura S, Manabe I, Nagasaki M, Eto K, Yamashita H, Ohsugi M, Otsu M, Hara K, Ueki K, Sugiura S, Yoshimura K, Kadowaki T, Nagai R.

Nat Med. 2009; 15; 914-920.

Adipose tissue inflammation in obesity and metabolic syndrome.EN

Nishimura S, Manabe I, Nagai R.

Discov Med. 2009; 8(41): 55-60.

Induction of factor VIII-specific unresponsiveness by intrathymic factor VIII injection in murine hemophilia A.EN

Madoiwa, S., Yamauchi,T., Kobayashi ,E., Hakamata, Y., Dokai, M., Makino, N., Kashiwakura,Y., Ishiwata, A., Ohmori,T., Mimuro,J., Sakata,Y.

J Thromb Haemost. 2009; 7(5): 811-824. 

In vivo imaging in mice reveals local cell dynamics and inflammation in obese adipose tissue.EN

Nishimura S, Manabe I, Nagasaki M, Seo K, Yamashita H, Hosoya Y, Ohsugi M, Tobe K, Kadowaki T, Nagai R, Sugiura S.

J Clin Invest. 2008; 118(2): 710-21.

Responses of single-ventricular myocytes to dynamic axial stretching.EN

Nishimura S, Seo K, Nagasaki M, Hosoya Y, Yamashita H, Fujita H, Nagai R, Sugiura S.

Prog Biophys Mol Biol. 2008; 97(2-3): 282-97.

Adipogenesis in obesity requires close interplay between differentiating adipocytes, stromal cells, and blood vessels.EN

Nishimura S, Manabe I, Nagasaki M, Hosoya Y, Yamashita H, Fujita H, Ohsugi M, Tobe K, Kadowaki T, Nagai R, Sugiura S.

Diabetes. 2007; 56(6): 1517-26.

Microtubules modulate the stiffness of cardiomyocytes against shear stress.EN

Nishimura S, Nagai S, Katoh M, Yamashita H, Saeki Y, Okada J, Hisada T, Nagai R, Sugiura S.

Circ Res. 2006; 98(1): 81-7.

Carbon fiber technique for the investigation of single-cell mechanics in intact cardiac myocytes.EN

Sugiura S, Nishimura S, Yasuda S, Hosoya Y, Katoh K.

Nat Protoc. 2006; 1(3): 1453-7.

Membrane potential of rat ventricular myocytes responds to axial stretch in phase, amplitude and speed-dependent manners.EN

Nishimura S, Kawai Y, Nakajima T, Hosoya Y, Fujita H, Katoh M, Yamashita H, Nagai R, Sugiura S.

Cardiovasc Res. 2006; 72(3): 403-11.

Expression of green fluorescent protein impairs the force-generating ability of isolated rat ventricular cardiomyocytes.EN

Nishimura S, Nagai S, Sata M, Katoh M, Yamashita H, Saeki Y, Nagai R, Sugiura S.

Mol Cell Biochem. 2006; 286(1-2): 59-65.

Contractile dysfunction of cardiomyopathic hamster myocytes is pronounced under high load conditions.EN

Nishimura S, Yamashita H, Katoh M, Yamada KP, Sunagawa K, Saeki Y, Ohnuki Y, Nagai R, Sugiura S.

J Mol Cell Cardiol. 2005; 39(2): 231-9.

Three-dimensional simulation of calcium waves and contraction in cardiomyocytes using the finite element method.EN

Okada J, Sugiura S, Nishimura S, Hisada T.

Am J Physiol Cell Physiol. 2005; 288(3): C510-22.

Single cell mechanics of rat cardiomyocytes under isometric, unloaded, and physiologically loaded conditions.EN

Nishimura S, Yasuda S, Katoh M, Yamada KP, Yamashita H, Saeki Y, Sunagawa K, Nagai R, Hisada T, Sugiura S.

Am J Physiol Heart Circ Physiol. 2004; 287(1): H196-202.

Unloaded shortening increases peak of Ca2+ transients but accelerates their decay in rat single cardiac myocytes.EN

Yasuda S, Sugiura S, Yamashita H, Nishimura S, Saeki Y, Momomura S, Katoh K, Nagai R, Sugi H.

Am J Physiol Heart Circ Physiol. 2003; 285(2): H470-5.

生体分子イメージングによる微小循環の可視化と病態解析.EN

西村 智

臨床高血圧1. 2013; 19(4): 12-18.

出血性疾患の診断アプローチ.EN

大森 司

臨床血液. 2013; 54(10): 1888-1896.

血清パラオキソナーゼ活性は抗血小板薬投与下の凝集能と関連しない.EN

大森司, 矢野裕一郎, 坂田飛鳥, 池本智一, 新保昌久, 窓岩清治, 勝木孝明, 三室淳,

島田和幸, 苅尾七臣, 坂田洋一

日本血栓止血学会誌. 2012; 23(2): 200.

第FVIII因子感作血友病Aマウスにおけるマイクロボードを用いた連続的抗原投与モデルの構築.EN

窓岩清治, 小林英司, 坂田飛鳥, 柏倉裕志, 大森司, 三室淳, 坂田洋一

第34回日本血栓止血学会学術集会.東京, 2012.6/7-9.

日本血栓止血学会誌. 2012; 23(2): 197.

出血傾向・血小板減少症の鑑別診断.EN

大森 司 

血液疾患の診断へのアプローチ.  2011: 48(10); p1704-1709   

medicina 医学書院. 

機械的伸展に対する心筋組織の膜電位応答とその数理モデルによる不整脈シミュレーション.EN

瀬尾欣也、稲垣正司、平林智子、杉町勝、杉浦清了、久田俊明

生体医工学誌, 2009; 47: 77-87.

抗血小板薬抵抗性の概念とその実態.EN

大森司

医学のあゆみ. 2009; 228(10); p1001-1006

メタボリックシンドロームを規定する血清修飾リン脂質EN

長崎実佳, 西村 智 

第54回 日本人間ドック学会学術大会, 浜松, 2013. 8/29-30.

血友病Aクローンブタ.EN

柏倉裕志, 三室淳, 大西彰, 岩元正樹, 窓岩清治,淵本大一郎, 鈴木俊一, 鈴木美佐枝, 千本昭一郎,石渡彰, 安本篤史, 坂田飛鳥, 大森司, 橋本径子, 矢崎智子, 坂田洋一

第35回日本血栓止血学会学術集会, 山形, 2013.5/30-6/1

日本血栓止血学会誌. 2013; 24(2); 227.

血栓溶解の基礎と血栓溶解療法のガイドライン-血栓溶解薬-特徴と保険適応.EN

窓岩清治

第5回日本血栓止血学会学術標準化委員会血栓溶解部会シンポジウム、東京, 2010.10.30.

悪性腫瘍と凝固線溶系.EN

窓岩清治

第47回東北血栓止血研究会(招待:特別講演)

2009.9.12 福島市